{"id":346,"date":"2026-08-02T13:04:12","date_gmt":"2026-08-02T11:04:12","guid":{"rendered":"https:\/\/wordpress-vsbv.srv1703136.hstgr.cloud\/product\/ghrp-2\/"},"modified":"2026-08-09T17:58:47","modified_gmt":"2026-08-09T15:58:47","slug":"ghrp-2","status":"publish","type":"product","link":"https:\/\/wordpress-vsbv.srv1703136.hstgr.cloud\/pl\/product\/ghrp-2\/","title":{"rendered":"GHRP-2"},"content":{"rendered":"<h3>What is GHRP-2?<\/h3>\n<p>GHRP-2 (Growth Hormone-Releasing Peptide-2) is a synthetic hexapeptide with the sequence D-Ala-D-2-Nal-Ala-Trp-D-Phe-Lys-NH\u2082, belonging to the class of hormone secretagons growth (GHS). The compound was developed as part of a research program aimed at identifying molecules capable of stimulating the release of growth hormone (GH) from the pituitary gland through a growth hormone-releasing hormone (GHRH)-independent mechanism.<\/p>\n<p>Structurally, GHRP-2 is characterized by the presence of D-amino acids (D-Ala, D-2-Nal, D-Phe), which make the molecule resistant to enzymatic degradation and extend the half-life compared to peptides composed only of L-amino acids. The molecular weight is approximately 818 Da and the molecular formula is C\u2084\u2085H\u2085\u2085N\u2089O\u2086. The presence of unnatural amino acids, such as D-2-naphthylalanine (D-2-Nal), is crucial for the high affinity for the growth hormone secretagon receptor.<\/p>\n<p>GHRP-2 acts as an agonist of the GHS-R1a receptor (Growth Hormone Secretagogue Receptor type 1a), which is also a natural receptor for ghrelin &#8211; an endogenous peptide hormone produced mainly in the stomach. The binding of GHRP-2 to GHS-R1a in the pituitary somatotropes leads to cell depolarization, influx of calcium ions and secretion of growth hormone in a pulsatile manner imitating the physiological secretion pattern.<\/p>\n<p>PMC<\/a><\/li>\n<li><strong>Bowers CY.<\/strong> Growth hormone-releasing peptide (GHRP). <em>Cell Mol Life Sci.<\/em> 1998;54(12):1316-1329. <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/9893709\/\">PubMed<\/a><\/li>\n<li><strong>Smith RG.<\/strong> Development of growth hormone secretagogues. <em>Endocr Rev.<\/em> 2005;26(3):346-360. <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/15814849\/\">PubMed<\/a><\/li>\n<li><strong>Popovic V et al.<\/strong> Serum ghrelin levels in patients with growth hormone deficiency evaluated with growth hormone releasing hormone-growth hormone releasing peptide-2 test. <em>J Clin Endocrinol Metab.<\/em> 2004;89(11):5478-5483. <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/15531499\/\">PubMed<\/a><\/li>\n<li><strong>Nass R et al.<\/strong> Effects of an oral ghrelin mimetic on body composition and clinical outcomes in healthy older adults: a randomized trial. <em>Ann Intern Med.<\/em> 2008;149(9):601-611. <a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC2757071\/\">PMC<\/a><\/li>\n<li><strong>Muccioli G et al.<\/strong> Growth hormone-releasing peptides and the cardiovascular system. <em>Ann Endocrinol (Paris).<\/em> 2000;61(1):27-31. <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/10762078\/\">PubMed<\/a><\/li>\n<li><strong>Vestergaard PF et al.<\/strong> Ghrelin and growth hormone secretagogues in health and disease. <em>Pituitary.<\/em> 2020;23(5):500-520. <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/32418116\/\">PubMed<\/a><\/li>\n<li><strong>Cordido F et al.<\/strong> Effect of combined administration of growth hormone (GH)-releasing hormone, GH-releasing peptide-6, and pyridostigmine in normal and obese subjects. <em>Metabolism.<\/em> 1995;44(6):745-748. <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/7783659\/\">PubMed<\/a><\/li>\n<li><strong>Laferr\u00e8re B et al.<\/strong> Growth hormone releasing peptide-2 (GHRP-2), like ghrelin, increases food intake in healthy men. <em>J Clin Endocrinol Metab.<\/em> 2005;90(2):611-614. <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/15699528\/\">PubMed<\/a><\/li>\n<li><strong>Micic D et al.<\/strong> Growth hormone secretagogues: clinical experience and perspectives. <em>Pediatr Endocrinol Rev.<\/em> 2008;5 Suppl 2:786-795. <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/18367504\/\">PubMed<\/a><\/li>\n<\/ol>\n","protected":false},"excerpt":{"rendered":"<p>Research peptide | Growth hormone secretagon | Ghrelin receptor agonist<\/p>\n","protected":false},"featured_media":0,"template":"","meta":[],"product_brand":[],"product_cat":[91],"product_tag":[],"class_list":["post-346","product","type-product","status-publish","product_cat-sekretagogi-hormonu-wzrostu","first","instock","taxable","shipping-taxable","purchasable","product-type-variable"],"_links":{"self":[{"href":"https:\/\/wordpress-vsbv.srv1703136.hstgr.cloud\/pl\/wp-json\/wp\/v2\/product\/346","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/wordpress-vsbv.srv1703136.hstgr.cloud\/pl\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/wordpress-vsbv.srv1703136.hstgr.cloud\/pl\/wp-json\/wp\/v2\/types\/product"}],"wp:attachment":[{"href":"https:\/\/wordpress-vsbv.srv1703136.hstgr.cloud\/pl\/wp-json\/wp\/v2\/media?parent=346"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/wordpress-vsbv.srv1703136.hstgr.cloud\/pl\/wp-json\/wp\/v2\/product_brand?post=346"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/wordpress-vsbv.srv1703136.hstgr.cloud\/pl\/wp-json\/wp\/v2\/product_cat?post=346"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/wordpress-vsbv.srv1703136.hstgr.cloud\/pl\/wp-json\/wp\/v2\/product_tag?post=346"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}